Archiv der Pharmazie p. 500 - 505 (1986)
Update date:2022-08-05
Topics:
Dannhardt
Steindl
The pyrrolizinyl substituted oxalic acid derivatives 1a or 1b are reduced to the diol 2, which on acidic hydrolysis given the title compound 3. PDC oxidation of the pyrrolizinylacetaldehyde 3 results in the degradation of the side chain at C-5 to yield the aldehyde 5 and the lactam 6. The diol 2 shows weak antiinflammatory activity.
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Doi:10.1248/cpb.42.534
(1994)Doi:10.1016/j.tetlet.2008.05.154
(2008)Doi:10.1021/ja8040543
(2008)Doi:10.1021/ja00235a019
(1987)Doi:10.1021/ja01265a073
()Doi:10.1002/jhet.5570450407
(2008)
