A NEW SYNTHESIS OF (+)-6a-CARBAPROSTAGLANDIN I2 EMPLOYING YEAST REDUCTION OF A β-KETO ESTER DERIVED FROM cis-BICYCLOOCTANE-3,7-DIONE AS THE KEY-STEP

DOI: 10.1016/S0040-4020(01)87443-3

Source and publish data:

Tetrahedron p. 435 - 444 (1986)

Update date:2022-07-29

Topics:

Authors:

Mori, Kenji

Tsuji, Masahiro

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Article abstract of DOI:10.1016/S0040-4020(01)87443-3

(+)-6a-carbaprostaglandin I2 (carbacyclin), a stable mimic of prostaglandin I2 (prostacyclin), was synthesized by utilizing the kinetic resolution of (+/-)-2-ethoxycarbonyl-7,7-ethylenedioxybicyclo<3.3.0>octan-3-one in the course of its yeast reduction as

Full text of DOI:10.1016/S0040-4020(01)87443-3

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