OPTISCH AKTIVE PHOSPHINE DURCH ASYMMETRISCHE SUBSTITUTION PROCHIRALER, HOMOCHIRAL SUBSTITUIERTER PHOSPHONITE

Article abstract of DOI:10.1016/0022-328X(86)80033-X

Phenylphosphonous acid dimenthylester and its dibornylester react with bulky nucleophiles to give diastereomeric phosphinous acid esters.The asymmetric induction is as high as 95 percent d.e.If reaction conditions favouring inversion at phosphorus are used then the (R)-menthoxy group of the prochiral starting material is substituted.The phosphinous acid ester can be converted, with partial racemization, into optically active Horner-phosphines.