Journal of Organic Chemistry p. 183 - 188 (1987)
Update date:2022-08-04
Topics:
Parker, Kathlyn A.
Spero, Denice M.
Koziski, Kathleen A.
Several approaches to trialkoxyphthalic acid derivatives, potential intermediates in a fredericamycin synthesis, were tested. Sequences based on a Diels-Alder/retro Diels-Alder reaction, a cyanide addition to a quinone, an Elbe oxidation, and an amide-directed ortho-lithiation are discussed in terms of length, yields, convenience, and the versatility of the product of each.
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Doi:10.1002/adsc.200800091
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(1961)Doi:10.3987/COM-13-S(S)13
(2014)Doi:10.1021/jm800066v
(2008)
