Piperazinealkanol ester derivatives of indomethacin as dual inhibitors of 5-lipoxygenase and cyclooxygenase

DOI: 10.1248/cpb.42.963

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 963 - 971 (1994)

Update date:2022-08-05

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Authors:

Yamawaki

Suzuki Suzuki

Ogawa Ogawa

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Article abstract of DOI:10.1248/cpb.42.963

Piperazinealkanol ester derivatives of indomethacin were prepared and tested for inhibitory activities against 5-lipoxygenase (5-LO) and cyclooxygenase (CO). They inhibited 5-hydroxyeicosatetraenoic acid (5-HETE) formation by the cytosol of guinea pig pol

Full text of DOI:10.1248/cpb.42.963

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