A Method for the Preparation of Stereochemically Defined ψ Pseudodipeptides

DOI: 10.1021/jo00379a019

Source and publish data:

Journal of Organic Chemistry p. 418 - 422 (1987)

Update date:2022-08-04

Topics:: Authors:

TenBrink, Ruth E.

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Article abstract of DOI:10.1021/jo00379a019

A short, stereochemically defined synthesis of (2S,5S)-ψ pseudodipeptides (7a,7b,10) using commercially available, chiral amino acids has been developed.The key step of the synthesis is the intramolecular S_N2 displacement of bromine with alkoxide to give 1,4-oxazin-2-ones (6a,6b,9) that are subsequently hydrolyzed to the desired ψ pseudodipeptides.

Full text of DOI:10.1021/jo00379a019

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A Method for the Preparation of Stereochemically Defined ψ Pseudodipeptides

DOI: 10.1021/jo00379a019

Source and publish data:

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Article abstract of DOI:10.1021/jo00379a019

Full text of DOI:10.1021/jo00379a019

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