3-(Imidazol-1-ylmethyl)-4',4''-dimethoxytrityl: A New Functionalized 5'-Hydroxyl Protecting Group Capable of Rapid Internucleotidic Bond Formation in the Phosphorothio Ester Approach

DOI: 10.1021/jo00381a047

Source and publish data:

Journal of Organic Chemistry p. 946 - 948 (1987)

Update date:2022-08-06

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Authors:

Sekine, Mitsuo

Hata, Tsujiaki

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Article abstract of DOI:10.1021/jo00381a047

A remarkable rate enhancement of internucleotidic bond formation in DNA synthesis has been achieved by use of 3-(imidazol-1-ylmethyl)-4',4''-dimethoxytrityl as a new 5'-hydroxyl protecting group which has a potential catalytic site for condensation.

Full text of DOI:10.1021/jo00381a047

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