Synthesis and Biological Activity of Novel Calcium Channel Blockers: 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic Acid Esters and 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic Acid Esters

DOI: 10.1021/jm00387a009

Source and publish data:

Journal of Medicinal Chemistry p. 635 - 640 (1987)

Update date:2022-08-05

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Authors:

Atwal, Karnail S.

Bergey, James L.

Hedberg, Anders

Moreland, Suzanne

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Article abstract of DOI:10.1021/jm00387a009

2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters, based on the structures of dihydropyridines and diltiazem, were synthesized from o-aminothiophenol and 2-(phenylmethylene)-3-oxobutanoic acid esters.Biological evaluation in the p

Full text of DOI:10.1021/jm00387a009

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