Potential Antitumor Agents. 50. In Vivo Solid-Tumor Activity of Derivatives of N-acridine-4-carboxamide

Article abstract of DOI:10.1021/jm00387a014

The synthesis, physicochemical properties, and antitumor activity of a series of N-<2-(dialkylamino)alkyl>acridine-4-carboxamides are reported.The compounds bind to DNA by intercalation, but exist under physiological conditions as monocations due to the w