Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives

DOI: 10.1021/jm00387a018

Source and publish data:

Journal of Medicinal Chemistry p. 682 - 689 (1987)

Update date:2022-08-05

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Authors:

Marshall

Goodson Goodson

Cullinan

Swanson-Bean

Haisch Haisch

Rinkema Rinkema

Fleisch Fleisch

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Article abstract of DOI:10.1021/jm00387a018

A series of derivatives of 2,4-dihydroxy-3-propylacetophenone were prepared and examined for their ability to block leukotriene D₄ (LTD₄) induced contraction of guinea pig ileum. Straight-chain carboxylic acids where the carboxyl gro

Full text of DOI:10.1021/jm00387a018

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