Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of PDE I and PDE II, Inhibitors of Cyclic Adenosine-3',5'-monophosphate Phosphodiesterase Using the 3,3'-Bipyrrole Strategy

Article abstract of DOI:10.1021/ja00243a026

In the model series tert-butyl 2,4-pentadienoate was treated with TosCHMeNC/NaH to give the pyrrole 18, which was converted into the 3,3'-bipyrrole 20.Treatment of the pyrrole 20 with oxalyl chloride gave the o-quinone 21, which was reduced and concomitan