Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of PDE I and PDE II, Inhibitors of Cyclic Adenosine-3',5'-monophosphate Phosphodiesterase Using the 3,3'-Bipyrrole Strategy

DOI: 10.1021/ja00243a026

Source and publish data:

Journal of the American Chemical Society p. 2711 - 2717 (1987)

Update date:2022-08-03

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Authors:

Carter, Paul

Fitzjohn, Steven

Halazy, Serge

Magnus, Philip

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Article abstract of DOI:10.1021/ja00243a026

In the model series tert-butyl 2,4-pentadienoate was treated with TosCHMeNC/NaH to give the pyrrole 18, which was converted into the 3,3'-bipyrrole 20.Treatment of the pyrrole 20 with oxalyl chloride gave the o-quinone 21, which was reduced and concomitan

Full text of DOI:10.1021/ja00243a026

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