Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase

Article abstract of DOI:10.1021/jm00126a022

The Boon-Leigh procedure, involving condensation of a 6-chloro-5-nitropyrimidine (22) with an α-amino ketone (20 or 21) followed by reduction of the nitro group, cyclization, and L-glutamylation, led to the formation of 11-deazahomofolate (29) and its 10-