Acid Catalyzed α-Alkylation of β-Aminothiophenes Using Aldehydes and Selenophenol. Synthesis of Bis(3-amino-2-thienyl)methane Derivatives

Article abstract of DOI:10.1016/S0040-4039(00)73841-X

The acid-catalyzed reaction between β-aminothiophenes and aldehydes, in the presence of selenophenol, leads to α-alkyl β-aminothiophenes.The reduction step is not observed with thiophenol.Without selenol, a second alkylation reaction occurs and bis(3-amin