Cyclization of Polyenes. 46. Synthesis of (+/-)-Asperdiol, an Anticancer Cembrenoid

DOI: 10.1021/jo00385a028

Source and publish data:

Journal of Organic Chemistry p. 1803 - 1810 (1987)

Update date:2022-09-26

Topics: Synthesis Polyenes Cyclization Anticancer

Authors:

Kato, Tadahiro

Aoki, Mario

Uyehara, Tadao

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Article abstract of DOI:10.1021/jo00385a028

On the basis of retrosynthetic perspective (Scheme I), the asperdiol skeleton (I = 24) and its geometrical isomer (II = 25) were constructed from cis- and trans-isopropenyl alcohols 3a and 3b.I(24) was converted into (+/-)-asperdiol 1 by the sequential re

Full text of DOI:10.1021/jo00385a028

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