Organic Letters p. 858 - 862 (2020)
Update date:2022-08-04
Topics:
Zeng, Weijun
Tan, Xuefeng
Yu, Yang
Chen, Gen-Qiang
Zhang, Xumu
A copper-catalyzed asymmetric hydrosilylation of β-nitroethyl aryl ketones has been disclosed, and the corresponding chiral alcohols could be obtained in high yields (up to 99% yield) and excellent enantioselectivities (up to 96% ee). Moreover, the reaction worked well on a gram scale with 0.3 mol % of ligand loading, indicating that our protocol has potential applications in the synthesis of important pharmaceuticals such as Tranylcypromine and Ticagrelor.
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Doi:10.1007/BF00930068
()Doi:10.1021/jo8014038
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