Molecules p. 2004 - 2028 (2014)
Update date:2022-08-04
Topics:
Li, Xingzhou
Zhou, Xinming
Zhang, Jing
Wang, Lili
Long, Long
Zheng, Zhibing
Li, Song
Zhong, Wu
A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-a production in lipopolysaccharide-stimulated THP-1 cells. The most active compound, 40g, inhibited TNF-a release with an IC50 value of 0.033 μM, which is equipotent to that of BIRB796 (IC50 = 0.032 μM).
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