Journal of Organic Chemistry p. 1487 - 1492 (1987)
Update date:2022-07-29
Topics: Synthesis Epoxide Chemical Reaction Protected Experimental α-amino acids
Luly, Jay R.
Dellaria, Joseph F.
Plattner, Jacob J.
Soderquist, Jeffrey L.
Yi, Nwe
The synthesis of alkylamino epoxides C is presented.Key steps include the synthesis of amino aldehyde 5 by reduction (DIBAH) of ester 3 or by oxidation of N-protected amino alcohol 4, both edducts of which are derived from amino acids.A study of the olefination of aldehyde 5 with unstabilized ylides is presented, and protected allylic amino 6, obtained in good to excellent optical purity, is oxidized (MCPBA) to epoxide C.Threo selectivity is observed in the epoxidation reaction.
View MoreContact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Wuhan Hanye Chemical New Material Co.,Ltd
Contact:+86-27-85308141
Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Suzhou Kangrun Pharmaceutical, Inc
Contact:86-512-63912376，63913329
Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
Nanjing Fayekong Chemcial Co.,Ltd(expird)
Contact:86-25-58813444
Address:Rm 1503, Unit 1, Building 5, Zijinnanyuan, Nanjing, Jiangsu, China
Shandong Jusage Technology Co.,Ltd.
Contact:86-13406130167
Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
Doi:10.1002/chir.22168
(2013)Doi:10.1021/jo8014598
(2008)Doi:10.1021/ja802423n
(2008)Doi:10.1021/ja01364a050
(1930)Doi:10.1016/S0040-4039(00)84728-0
(1986)Doi:10.1016/j.bmcl.2015.12.062
(2016)
