Journal of Organic Chemistry p. 1487 - 1492 (1987)
Update date:2022-07-29
Topics: Synthesis Epoxide Chemical Reaction Protected Experimental α-amino acids
Luly, Jay R.
Dellaria, Joseph F.
Plattner, Jacob J.
Soderquist, Jeffrey L.
Yi, Nwe
The synthesis of alkylamino epoxides C is presented.Key steps include the synthesis of amino aldehyde 5 by reduction (DIBAH) of ester 3 or by oxidation of N-protected amino alcohol 4, both edducts of which are derived from amino acids.A study of the olefination of aldehyde 5 with unstabilized ylides is presented, and protected allylic amino 6, obtained in good to excellent optical purity, is oxidized (MCPBA) to epoxide C.Threo selectivity is observed in the epoxidation reaction.
View MoreShanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
Contact:86-532-68629711 13780605697
Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
Jinan Baozhao Pharmaceutical Co., Ltd
Contact:0086-531-86397156 82371858 82371868
Address:Huaneng Road, Jinan, Shandong ,China
Zibo Linzi Darong Fine Chemical Co., Ltd(expird)
Contact:86-532-67773200; 15689126900
Address:Qidu town,Linzi district,Zibo city,Shandong province,China
Doi:10.1002/chir.22168
(2013)Doi:10.1021/jo8014598
(2008)Doi:10.1021/ja802423n
(2008)Doi:10.1021/ja01364a050
(1930)Doi:10.1016/S0040-4039(00)84728-0
(1986)Doi:10.1016/j.bmcl.2015.12.062
(2016)
