Tetrahedron p. 4461 - 4470 (1986)
Update date:2022-08-04
Topics:
Pochat, Francis
Reaction of 6-amino-3-cyano-5-methylthio-2-pyridones, 1, with Vilsmeier reagent leads to protection of the amino group as the formamidine, allowing facile reaction with thionyl chloride to give 6-amino-2,5-dichloro nicotinonitriles, 4.This technique is co
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