Quantitative Analyses of Biochemical Kinetic Resolution of Enantiomers. 2. Enzyme-Catalyzed Esterification in Water-Organic Solvent Biphasic Systems

Article abstract of DOI:10.1021/ja00243a040

New quantitative expressions, which relate the kinetic and thermodynamic parameters that govern the stereospecificity of enzyme-catalyzed resolution of enantiomers in biphasic aqueous-organic media, have been developed.The theoretical predictions have been verified experimentally, and the technical merit of this esterification methodology has been assessed in relation to the more conventional hydrolytic procedure.