CROSS-COUPLING OF 2-CHLOROBENZOXAZOLE WITH β,γ-UNSATURATED GRIGNARD REAGENTS: REGIOSELECTIVE SYNTHESIS OF 2-ALLYL-, 2-ALLENYL-, AND 2-PROPARGYL-BENZOXAZOLES.

Article abstract of DOI:10.1016/S0040-4020(01)87545-1

β,γ-unsaturated Grignard reagents react regioselectively with 2-chlorobenzoxazole to give high to excellent yields of 2-allyl-, 2-allenyl-, and 2-propargyl-bezoxazoles.Reduction of allylbenzoxazoles leads to quantitative yields of branched 2-alkylbenzoxazoles.