CHEMISTRY OF HETEROCYCLIC N-OXIDES AND RELATED COMPOUNDS. ACYLAMINATION OF PYRIDINE N-OXIDE BY ANILINE, p-ANISIDINE, AND THEIR N-p-TOSYL DERIVATIVES

Article abstract of DOI:10.1007/BF00522734

Acylamination of pyridine N-oxide by aniline, p-anisidine, and their tosyl derivatives was carried out in an alkaline medium in the presence of p-tosyl chloride.The reaction proceeds selectively with the formation of the corresponding 2-(N-p-tosyl)anilino- and 2-p-(N-p-tosyl)anisidino-pyridines.The reaction products were converted by acid hydrolysis into the corresponding 2-anilinopyridines.