Journal of Organic Chemistry p. 2838 - 2848 (1987)
Update date:2022-08-03
Topics:
Findeis, Mark A.
Whitesides, George M.
This paper describes the use of pig heart fumarase (E.C. 4.2.1.2) as a catalyst in the multigram synthesis of L-threo-chloromalic acid (1) (>99.5percent enantiomeric excess) on 50-g scale.L-threo-Fluoromalic acid has been synthesized in a coupled enzymic system from difluorofumaric acid.Compound 1 serves as starting material for syntheses of 2-deoxy-D-ribose and D-erythro-sphingosine.
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