An efficient synthesis of 1,8-naphthyridin-2(1H)-ones: Synthesis of leukotriene inhibitor SCH 37224

Article abstract of DOI:10.1055/s-1991-26519

A new, efficient synthesis of 1,8-naphthyridin-2(1H)-ones as applied to the synthesis of the leukotriene release inhibitor, 1,2-dihydro-1-phenyl-3-pyrrolidinio-2-oxo-1,8-naphthyridin-4-olate inner salt (4) from methyl 2-phenylamino-3-pyridinecarboxylate,