Synthesis of β-amino-α,α-difluoroketones by reactions of 1,1-difluorovinyl methyl ethers with N-acyliminium intermediates

Article abstract of DOI:10.1016/0040-4039(95)02348-8

An efficient preparation of β-amino-2a,α-difluoroketones 4 was developed. Reactions of 1,1-difluorovinyl methyl esters 1 with N-acyliminium intermediates, generated by treating biscarbamates 2 with trifluoromethanesulfonic anhydride (Tf₂O) in t