gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity

DOI: 10.1021/jm00391a027

Source and publish data:

Journal of Medicinal Chemistry p. 1426 - 1433 (1987)

Update date:2022-08-04

Topics: In vitro Chromatography Mass spectrometry (MS) Nuclear Magnetic Resonance (NMR) Enzyme inhibition in vivo Purification Structure-Activity Relationship (SAR) Biological Activity Synthetic Chemistry Spectroscopic Analysis Cell-based assay Phosphonate Phosphate

Authors:

Nguyen Nguyen

Niesor Niesor

Bentzen Bentzen

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Article abstract of DOI:10.1021/jm00391a027

New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of nume

Full text of DOI:10.1021/jm00391a027

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