Synthesis of Glycopyranosylphosphonate Analogues of Certain Natural Nucleoside Diphosphate Sugars as Potential Inhibitors of Glycosyltransferases

DOI: 10.1021/jm00391a020

Source and publish data:

Journal of Medicinal Chemistry p. 1383 - 1391 (1987)

Update date:2022-07-29

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Authors:

Vaghefi, Morteza M.

Bernacki, Ralph J.

Dalley, N. Kent

Wilson, Bruce E.

Robins, Roland K.

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Article abstract of DOI:10.1021/jm00391a020

The synthesis of α-D-glucopyranosyl-, α-D-galactopyranosyl-, and α-D-mannopyranosylphosphonate is described.Condensation of tris(trimethylsilyl)phosphite with 2,3,4,6-tetrakis-O-(phenylmethyl)-1-O-acetyl-α-D-glucopyranose generated 2,3,4,6-tetrakis-O-(phe

Full text of DOI:10.1021/jm00391a020

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