Synthesis of Glycopyranosylphosphonate Analogues of Certain Natural Nucleoside Diphosphate Sugars as Potential Inhibitors of Glycosyltransferases

Article abstract of DOI:10.1021/jm00391a020

The synthesis of α-D-glucopyranosyl-, α-D-galactopyranosyl-, and α-D-mannopyranosylphosphonate is described.Condensation of tris(trimethylsilyl)phosphite with 2,3,4,6-tetrakis-O-(phenylmethyl)-1-O-acetyl-α-D-glucopyranose generated 2,3,4,6-tetrakis-O-(phe