SYNTHESIS OF AN OPTICALLY ACTIVE SPERMINE MACROCYCLE, (S)-6-(HYDROXYMETHYL)-1,5,10,14-TETRAAZACYCLOOCTADECANE, AND ITS COMPLEXATION TO ATP

Article abstract of DOI:10.1016/S0040-4039(00)85368-X

The title compound was prepared in high yield from L-ornithine via a Richman-Atkins type macrocyclization. ³¹P-NMR binding studies indicate formation of a 1:1 complex of the protonated macrocycle with ATP.