Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

DOI: 10.1016/j.bmcl.2011.12.130

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1591 - 1597 (2012)

Update date:2022-08-03

Topics:

Authors:

Pastor, Joaquín

Oyarzabal, Julen

Saluste, Gustavo

Alvarez, Rosa María

Rivero, Virginia

Ramos, Francisco

Cendón, Elena

Blanco-Aparicio, Carmen

Ajenjo, Nuria

Cebriá, Antonio

Albarrán

Cebrián, David

Corrionero, Ana

Fominaya, Jesús

Montoya, Guillermo

Mazzorana, Marco

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Article abstract of DOI:10.1016/j.bmcl.2011.12.130

PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approa

Full text of DOI:10.1016/j.bmcl.2011.12.130

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