Crystal structure of the covalent complex formed by a peptidyl α,α-difluoro-β-keto amide with porcine pancreatic elastase at 1.78-A resolution

Article abstract of DOI:10.1021/ja00191a039

The crystal structure analysis of the covalent enzyme-inhibitor complex of porcine pancreatic elastase (PPE) with a peptidyl α,α-difluoro-β-keto amide has shown that the tightly bound inhibitor forms an hemiketal complex with the O(γ) atom of the catalyti