Synthetic Studies toward Ciguatoxin. Stereocontrolled Construction of the KLM Ring Fragment

Article abstract of DOI:10.1021/jo00083a008

The first stereoselective synthesis of the KLM ring fragment of ciguatoxin is reported including as a key step 7-endo selective cyclization of epoxy alcohol to construct a fully substituted oxepane ring (12 -> 13).