Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine

DOI: 10.1021/jm00394a014

Source and publish data:

Journal of Medicinal Chemistry p. 2008 - 2012 (1987)

Update date:2022-08-04

Topics:

Authors:

Thorberg

Berg Berg

Lundstrom

Pettersson

Wijkstrom

Sanchez Sanchez

Lindberg

Nilsson Nilsson

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Article abstract of DOI:10.1021/jm00394a014

Twenty derivatives bearing substituents on the phenolic function of (-)-3-(3-hydroxyphenyl)-N-propylpiperidine [(-)-3-PPP] were synthesized and tested as prodrugs. The carbamate ester derivatives were found to be the most suitable prodrugs, and especially

Full text of DOI:10.1021/jm00394a014

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