Tetrahedron Letters p. 51 - 54 (1987)
Update date:2022-08-04
Topics:
Schulhof, J. C.
Molko, D.
Teoule, R.
New base protecting groups are proposed in place of benzoyl and isobutyryl groups.They are phenoxy acetyl for adenine and guanine and isobutyryl for cytosine.They are cleaved in aqueous ammonia in a shorter time at lower temperature.These easily removable groups are useful in the synthesis of modified oligonucleotides, containing fragile bases.
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