DOUBLE HYDROXYLATION OF ENOL SILYL ETHERS. A SINGLE-STEP SYNTHESIS OF α,α'-DIHYDROXY KETONES

Article abstract of DOI:10.1016/S0040-4039(00)99233-5

Oxidation of the more substituted regioisomer of the enol silyl ether of a methyl sec-alkyl ketone with 2 equiv of m-chloroperbenzoic acid in the presence of KHCO3 gives, after acidic workup, an α,α'-dihydroxylated ketone in high yield.Applications to the