A facile and efficient method for macrolactamization

Article abstract of DOI:10.1016/0040-4039(90)80098-7

Using 2-bromo-1-methylpyridinium iodide as carboxyl activating agent, 10 ansa-macrolactams were prepared conveniently from the corresponding seco-precursor ω-amino acids. In most cases the yields are excellent.