A Convenient Preparation of Optically Acitve 1,1'-Binaphthyl-2,2'-diol via Enzymatic Hydrolysis of the Racemic Diester

Article abstract of DOI:10.1246/cl.1987.355

Commercially available porcine pancreatic lipase can conveniently be utilized for a highly enantioselective hydrolysis of valeric acid diester of racemic 1,1'-binaphthyl-2,2'-diol to gave the (S)-diol (95percent ee at 46 percent conversion).