European Journal of Medicinal Chemistry p. 721 - 726 (1993)
Update date:2022-07-29
Topics:
Moinet-Hedin, V.
Tabka, T.
Gauduchon, P.
Talaer, J. Y. Le
Letois, B.
et al.
A series of 5,11-dimethyl-6H-pyrido<3,2-b>carbazoles, structurally related to the antitumor drug ellipticine, were synthesized from 3-amino-1,4-dimethyl-9H-carbazole.Among 17 derivatives, bearing various substituents on the pyridine ring, and preliminarily evaluated for cytotoxicity on L1210-cultured cells, 13 (76percent) were found to be active.One of them, 5,11-dimethyl-4-ethoxy-6H-pyrido<3,2-b>carbazole, although non-substituted on C-9, displayed an activity similar to that of 9-hydroxy-N-2-methyl-ellipticinium acetate.Structure-activity relationships have been described in detail. cytotoxicity/leukemia L1210/clonogenic assay/pyrido<3,2-b>carbazoles
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