1-Amino-Substituted 4-Methyl-5H-pyridoindoles (γ-Carbolines) as Tricyclic Analogues of Ellipticines: A New Class of Antineoplastic Agents

DOI: 10.1021/jm00397a023

Source and publish data:

Journal of Medicinal Chemistry p. 398 - 405 (1988)

Update date:2022-08-04

Topics:

Authors:

Bisagni, Emile

Nguyen, Chi Hung

Pierre, Alain

Pepin, Odile

Cointet, Paul de

Gros, Pierre

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Article abstract of DOI:10.1021/jm00397a023

A series of 1-amino-substituted 4-methyl-5H-pyrido<4,3>indoles that are structurally related to ellipticines by deletion of a ring have been synthesized in order to evaluate their DNA affinity, their in vitro cytotoxicity on L1210 cultured cells, and thei

Full text of DOI:10.1021/jm00397a023

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