Renin Inhibitors. Design and Synthesis of a New Class of Conformationally Restricted Analogues of Angiotensinogen

Article abstract of DOI:10.1021/jm00397a003

Molecular modeling methods have been used to design a novel series of conformationally constrained cyclic peptide inhibitors of human renin.Three goals were defined: enhanced inhibitory potency, high specificity for renin, and increased metabolic stabilit