Journal of Medicinal Chemistry p. 284 - 295 (1988)
Update date:2022-08-03
Topics:
Sham, Hing L.
Bolis, Giorgio
Stein, Herman H.
Fesik, Stephen W.
Marcotte, Patric A.
et al.
Molecular modeling methods have been used to design a novel series of conformationally constrained cyclic peptide inhibitors of human renin.Three goals were defined: enhanced inhibitory potency, high specificity for renin, and increased metabolic stabilit
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