Deblocking of dithioacetals and oxathioacetals using periodic acid under mild nonaqueous conditions

Article abstract of DOI:10.1016/0040-4039(96)00838-6

A novel method for the deblocking of the dithioacetals and oxathioacetals is described. Periodic acid under nonaqueous conditions has been used for the deprotection of the dithio- and oxathio-derivatives to the corresponding carbonyl compounds. This simple high-yield transformation is conveniently carried out in nonaqueous medium and works well with complex sensitive aldehydes and in the presence of other protective groups.