Tetrahedron Letters p. 1511 - 1514 (1994)
Update date:2022-07-29
Topics: Asymmetric synthesis Enantiomeric purity β-amino alcohols
Beardsley, David A.
Fisher, Gary B.
Goralski, Christian T.
Nicholson, Lawrence W.
Singaram, Bakthan
The asymmetric reduction of 2-amino acetophenones with Ipc2BH or Ipc2BCl at -78 deg C, yields the corresponding β-amino alcohols in good to excellent yields.Although only modest (12-45percent ee) enantiomeric excesses were obtained with Ipc2BH, 75-99perce
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