Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures

Article abstract of DOI:10.1016/j.bmc.2013.04.053

Many synthetic retinoids contain an aromatic structure with a bulky hydrophobic fragment. In order to obtain retinoids with therapeutic potential that do not bind to or activate retinoic acid X receptors (RXRs), we focused on the introduction of novel hyd