1
5
effective at enhancing the therapeutic index of an anticancer
drug than either mechanism alone. We believe that this
dual strategy is of particular value for those therapeutic
applications that require non-invasive and spatiotemporal
drug activation. Future efforts to enhance the scope of poten-
tial in vivo applications will focus on investigating the use of
longer wavelength light and two-photon excitation.14,15,27
This work was supported by the National Cancer Institute,
National Institutes of Health under award 1 R01 CA119409
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(J. R. B.). We thank Dr Pascale Leroueil for her expert 10
proofreading of the manuscript.
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ꢁc
This journal is The Royal Society of Chemistry 2010
2634 | Chem. Commun., 2010, 46, 2632–2634