ASYMMETRIC SYNTHESIS XI : A SHORT SYNTHESIS OF THE CHIRAL PYRROLIDINE SYNTHON, 2-CYANO-5-OXAZOLOPYRROLIDINE

DOI: 10.1016/S0040-4039(00)61839-7

Source and publish data:

Tetrahedron Letters p. 6175 - 6178 (1987)

Update date:2022-08-03

Topics:

Authors:

Royer, Jacques

Husson, Henri-Philippe

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Article abstract of DOI:10.1016/S0040-4039(00)61839-7

The Robinson-Schopf condensation of dimethoxytetrahydrofuran with R(-)phenylglycinol in the presence of KCN followed by reflux in ethanol leads to the formation of 2-cyano-5-oxazolopyrrolidine 1b in 52percent overall yield.

Full text of DOI:10.1016/S0040-4039(00)61839-7

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