Dehydro keto methylene and keto methylene analogues of substance P. Synthesis and biological activity

DOI: 10.1021/jm00397a026

Source and publish data:

Journal of Medicinal Chemistry p. 416 - 421 (1988)

Update date:2022-07-29

Topics:

Authors:

Ewenson Ewenson

Laufer Laufer

Chorev Chorev

Selinger

Gilon Gilon

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Article abstract of DOI:10.1021/jm00397a026

The synthesis of dehydro keto methylene and keto methylene analogues of substance P using classical peptide synthesis is described. The following analogues were prepared: [pGlu⁶,Gly⁹ψ(COCH₂)(RS)Leu¹⁰]SP_6-11

Full text of DOI:10.1021/jm00397a026

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Product name:Boc-(RS)Pheψ(COCH2)(RS)Phe-Gly-Leu-Met-NH2

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