Journal of Medicinal Chemistry p. 1265 - 1272 (1989)
Update date:2022-07-29
Topics:
Amemiya, Yoshiya
Terada, Atsusuke
Wachi, Kazuyuki
Miyazawa, Hachio
Hatakeyama, Naoko
et al.
1-Imidazolylalkyl-substituted di- or tetrahydrobenzothiophenecarboxylic acid derivatives and related compounds were synthesized from tetrahydrobenzothiophene derivatives (1 or 4) in order to study the structure-activity relationships of the inhibition of thromboxane A2 synthetase in vitro.Sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzothiophene-6-carboxylate (26) and 2-(1-imidazolylmethyl)-4,5,6,7-tetrahydrobenzothiophene-6-carboxylic acid hydrochloride (28) showed the most potent and specific activity in vitro and in vivo for thromboxane A2 synthetase inhibition.
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