A Facile Synthesis of Statine and Analogues by Reduction of β-Keto Esters Derived from Boc-Protected Amino Acids. HPLC Analyses of Their Enantiomeric Purity

Article abstract of DOI:10.1021/jo00239a035

The synthesis of γ-amino-β-keto ester derivatives 3a-e from N-Boc-protected L-amino acids by N,N'-carbonyldiimidazole activation and treatment with the magnesium enolate of hydrogen ethyl malonate is described.Racemization during activation, which depende