Asymmetric Reduction of α-Methylene Ketones by Using Fermenting Baker's Yeast. Preparation of Optically Active β-Hydroxy α-Methyl Ketones

DOI: 10.1246/cl.1987.971

Source and publish data:

Chemistry Letters p. 971 - 972 (1987)

Update date:2022-09-26

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Authors:

Utaka, Masanori

Onoue, Shinji

Takeda, Akira

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Article abstract of DOI:10.1246/cl.1987.971

Asymmetric reduction of 4-hydroxy-3-methylenealkan-2-ones with baker's yeast afforded (3R,4S)-4-hydroxy-3-methylalkan-2-ones in >98percent ee and the (3R,4R) isomers in 67 -> 98 percent ee in ratios of 1:1-2.

Full text of DOI:10.1246/cl.1987.971

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