Synthesis of highly functionalized barbituric acids and study of their interactions with p-glycoprotein and Mg2+ - Potential candidates for multi drug resistance modulation

Article abstract of DOI:10.1016/j.ejmech.2009.12.033

A number of barbituric acids with appropriate substituent at C-5 position were synthesized and investigated for their interactions with p-gp and Mg²⁺. Compounds 5, 6, 8-10, 12-14 and 16 increased the basal activity of p-gp by more than 50% at 0