SYNTHESIS OF GUANIN 7-OXIDE, AN ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES SPECIES

Article abstract of DOI:10.1016/S0040-4039(00)95348-6

The first synthesis of the antitumor antibiotic guanine 7-oxide (VI) has been achived via a 4-step route starting from phenacyl bromide (I) and the nitropyrimidone III and proceeding through the intermediates IVe and Ve.