SYNTHESIS OF GUANIN 7-OXIDE, AN ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES SPECIES

DOI: 10.1016/S0040-4039(00)95348-6

Source and publish data:

Tetrahedron Letters p. 1287 - 1290 (1987)

Update date:2022-08-03

Topics:

Authors:

Nohara, Fujio

Nishii, Masahiro

Ogawa, Kazuo

Isono, Kiyoshi

Ubukata, Makoto

et. al et. al

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Article abstract of DOI:10.1016/S0040-4039(00)95348-6

The first synthesis of the antitumor antibiotic guanine 7-oxide (VI) has been achived via a 4-step route starting from phenacyl bromide (I) and the nitropyrimidone III and proceeding through the intermediates IVe and Ve.

Full text of DOI:10.1016/S0040-4039(00)95348-6

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