Synthesis of a Biologically Active Vitamine-D2 Metabolite

DOI: 10.1021/jo00058a034

Source and publish data:

Journal of Organic Chemistry p. 1496 - 1500 (1993)

Update date:2022-08-04

Topics: Synthesis Metabolite biologically active

Authors:

Choudhry, Satish C.

Belica, Peter S.

Coffen, David L.

Focella, Antonino

Maehr, Hubert

et al. et al.

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Article abstract of DOI:10.1021/jo00058a034

The synthesis of 1α,25,28-trihydroxyvitamin-D₂ (1) from vitamin-D₂ is described.Approaches to the upper side-chain synthon via the chiral sulfone 15, prepared either through the enzymatic resolution of 10 or the opening of the optica

Full text of DOI:10.1021/jo00058a034

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